On average, it takes about 5-7 days before Botox kicks in. The amount of Botox required to get effective results varies for each person. Some people will get the results they want with just one treatment, whereas others may require multiple treatments to determine what the right dose is for them. If you have deeper wrinkles in the frown line area (glabellar region) you may require more than the average number of units to get the best results. This is why it’s important that you continue to follow up with your injector so that you can get your desired result. I like to have my clients return for follow-up 2 weeks after their initial treatment. If they need additional Botox then we give it at the follow-up appointment. This also protects against giving too much Botox right from the start and ending up with an expressionless mask face. In some cases, the deep frown lines do not completely go away. Dermal fillers like Belotero can then be used to smooth out whatever deep wrinkles remain after the Botox has taken effect. With a successful and natural result, you should still be able to maintain your natural expressions.